Milk thistle: early seeds of potential

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Milk Thistle Benefits & Information

The active ingredient, or liver-protecting compound in milk thistle is known as silymarin. This substance, which actually consists of a group of compounds called flavonolignands, helps repair liver cells damaged by alcohol and other toxic substances by stimulating protein synthesis. By changing the outside layer of liver cells, it also prevents certain toxins from getting inside. Silymarin also...

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Milk Thistle (Silybum marianum)

Milk thistle is a well known and commonly used herb, used particularly in hepatic diseases. It has very potent antioxidant, anti-inflammatory, and antifibrotic properties (1). As a single agent its therapeutic effects in liver disease appear to be modest (2,3,4,5). Herbal medicines and supplements are likely to be much more beneficial when used synergistically in combinations or formulas. Milk ...

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Milk Thistle and the Liver: Recent Findings

The standardized extract contains flavonolignans, collectively referred to as silymarin. Sometimes the extract itself is called “silymarin”, which can lead to confusion over dosage since the level of flavonolignans (silymarin) in the extract is typically 60 to 80%, depending on the test methodology used. The main flavonolignans found in the extract are silybin (silibin), silychristin, silydiani...

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Silymarin, Natural Flavonolignans from Milk Thistle

Plants are a valuable source of pharmaceuticals, food ingredients, agrochemicals, insecticides, flavors and pigments. These compounds are called secondary metabolites. These are compounds with a restricted occurrence in taxonomic groups that are not essential for an organism to live but play a role in the interaction of the organism with its environment, ensuring the survival of the organism in...

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Identification of Isosilybin A from Milk Thistle Seeds as an Agonist of Peroxisome Proliferator-Activated Receptor Gamma

Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of glucose and lipid metabolism. Agonists of this nuclear receptor are used in the treatment of type 2 diabetes and are also studied as a potential treatment of other metabolic diseases, including nonalcoholic fatty liver disease. Silymarin, a concentrated phenolic mixture from milk thistle (Silybum marianum) seeds, is ...

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ژورنال

عنوان ژورنال: The Lancet Oncology

سال: 2013

ISSN: 1470-2045

DOI: 10.1016/s1470-2045(13)70414-5